Quick Overview

High-purity Melanotan I (Afamelanotide), a linear synthetic peptide analog of alpha-melanocyte-stimulating hormone ($\alpha$-MSH), synthesized specifically for in vitro laboratory research and development. Formulated as a sterile, lyophilized powder to ensure maximum stability and precision in melanocortin receptor and cellular signaling assays.

Product Description

Melanotan I, also known as Afamelanotide or NDP-MSH, is a 13-amino-acid synthetic polypeptide modeled after the natural hormone $\alpha$-MSH. Structurally engineered to show enhanced binding affinity to melanocortin receptors—particularly the melanocortin-1 receptor (MC1R)—it exhibits significantly prolonged half-life and biological activity compared to the native hormone. In vitro, Melanotan I serves as a critical agent for scientists investigating melanogenesis pathways, receptor binding kinetics, and cellular protection models against ultraviolet-induced stress.

Common Research Applications:

• Receptor Binding Assays: Investigating MC1R, MC3R, and MC4R activation kinetics and secondary messenger cascades (cAMP production).
• Melanogenesis Studies: Observing the cellular mechanisms of melanin synthesis, pigment distribution, and melanocyte stimulation.
• Photoprotection Models: Assessing cellular responses and DNA repair pathways under oxidative and ultraviolet stress models.
• Enzymatic Stability: Analyzing structural modifications that impart resistance against rapid serum enzymatic degradation.

Technical Specifications

Storage and Reconstitution

To maintain peptide integrity and stability, please adhere to standard laboratory handling guidelines:

• Lyophilized Form (Dry Powder): Store desiccated at -20°C (or below) upon receipt. While stable at room temperature for brief transit periods, long-term freezing is required to prevent degradation.
• Reconstitution: Reconstitute using bacteriostatic water, sterile water, or 0.1% aqueous TFA. Introduce the diluent carefully and gently swirl the vial until dissolved. Do not shake vigorously, as this can fracture the peptide bonds.
• Liquid Storage (Reconstituted): Once reconstituted, store the solution at 2°C to 8°C (refrigerated) and utilize within standard laboratory storage windows (typically 14-30 days). For extended experimental timelines, aliquot the solution into individual vials and freeze at -20°C to avoid repeated freeze-thaw cycles.

Regulatory & Safety Disclaimer