Quick Overview
High-purity TB-500 (Thymosin Beta-4 active fragment), a synthetic peptide synthesized specifically for in vitro laboratory research and development. Formulated as a sterile, lyophilized powder to ensure maximum stability and precision in cellular migration, tissue repair, and actin-binding assay models.
Product Description
TB-500 is a synthetic version of the active actin-sequestering domain of Thymosin Beta-4 (β4), a naturally occurring ubiquitous peptide found in various tissues and cell types. Structurally designed around the core LKKTETQ amino acid sequence, it plays a fundamental role in regulating cellular cytoskeleton dynamics, endothelial cell differentiation, and tissue regeneration. In vitro, TB-500 is extensively utilized by scientific professionals to study cellular migration kinetics, angiogenesis pathways, and anti-inflammatory cellular responses.
Common Research Applications:
- Actin Sequestration Studies: Investigating the regulation of actin polymerization and cytoskeletal organization in cellular models.
- Tissue Regeneration Assays: Observing cellular migration, wound closure kinetics, and tissue repair pathways.
- Angiogenesis & Endothelial Research: Assessing blood vessel formation mechanics and endothelial cell proliferation dynamics.
- Anti-Inflammatory Pathways: Analyzing localized cytokine modulation and cellular defense mechanisms under induced stress assays.
Technical Specifications
| Compound Name | TB-500 (Thymosin β4 Fragment) |
|---|---|
| CAS Number | 77591-33-4 |
| Molecular Formula | C38H68N10O14 |
| Molecular Weight | 888.99 g/mol |
| Peptide Sequence | Ac-LKKTETQ-OH (Active Fragment) |
| Purity (HPLC) | ≥98.0% |
| Appearance | White lyophilized solid |
| Solubility | Soluble in sterile water or bacteriostatic water |
Storage and Reconstitution
To maintain peptide integrity and stability, please adhere to standard laboratory handling guidelines:
- Lyophilized Form (Dry Powder): Store desiccated at -20°C (or below) upon receipt. While stable at room temperature for brief transit periods, long-term freezing is required to prevent degradation.
- Reconstitution: Reconstitute using bacteriostatic water or sterile water for injection. Introduce the diluent carefully and gently swirl the vial until dissolved. Do not shake vigorously, as this can fracture the peptide bonds.
- Liquid Storage (Reconstituted): Once reconstituted, the solution should be stored at 2°C to 8°C (refrigerated) and utilized within 14 to 30 days. For extended experimental timelines, aliquot the solution into individual vials and freeze at -20°C to avoid repeated freeze-thaw cycles.
Regulatory & Safety Disclaimer
NOTICE TO BUYER: By purchasing this product, you legally acknowledge and agree that it is strictly for Research Use Only (RUO). It is unequivocally prohibited to be used as a drug, food additive, cosmetic, or household chemical.
- Not for Human or Animal Use: This material has not been evaluated or approved by the FDA (or any other international regulatory agency) for therapeutic, diagnostic, or clinical use.
- Qualified Personnel: This product must be handled exclusively by qualified scientific professionals in a regulated laboratory setting, utilizing standard safety and sterile protocols.
- Liability: The purchaser assumes all risks and liabilities associated with the handling, storage, and experimental application of this product.
1 review for TB-500
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duguaydev –
Unbelievable!