Quick Overview

High-purity Mechano Growth Factor (MGF), an alternatively spliced variant of IGF-1, synthesized specifically for in vitro laboratory research and development. Formulated as a sterile, lyophilized powder to ensure maximum stability and precision in cellular proliferation and tissue repair assays.

Product Description

Mechano Growth Factor (MGF), technically known as IGF-1Ec in humans, is a 24-amino-acid peptide derived from the alternative splicing of the Insulin-like Growth Factor 1 (IGF-1) gene. Naturally expressed in skeletal muscle in response to mechanical overload or cellular damage, MGF plays a crucial role in initiating localized tissue repair. In vitro, it demonstrates a unique ability to stimulate satellite cell (muscle stem cell) activation and proliferation, independent of the systemic IGF-1 receptor pathways. This makes it an invaluable compound for researchers studying tissue regeneration, cellular aging, and muscle hypertrophy models.

Common Research Applications:

• Myogenesis Studies: Investigating the activation, proliferation, and differentiation of muscle satellite cells.
• Tissue Regeneration Models: Studying localized cellular responses to mechanical stress and induced micro-damage.
• Neuroprotection Assays: Exploring the neuroprotective properties and motor neuron preservation mechanisms of MGF variants in vitro.
• Cellular Aging & Senescence: Analyzing the age-related decline in natural stem cell pools and the restorative impact of localized growth factors.

Technical Specifications

Storage and Reconstitution

To maintain peptide integrity and stability, please adhere to standard laboratory handling guidelines:

• Lyophilized Form (Dry Powder): Store desiccated at -20°C (or below) upon receipt. While stable at room temperature for brief transit periods, long-term freezing is required to prevent rapid degradation.
• Reconstitution: Reconstitute using bacteriostatic water or sterile water for injection. Introduce the diluent carefully and gently swirl the vial until completely dissolved. Do not shake vigorously, as this can fracture delicate peptide bonds.
• Liquid Storage (Reconstituted): Once reconstituted, MGF is highly sensitive to degradation. The solution should be stored at 2°C to 8°C (refrigerated) and utilized within 14 to 30 days. For extended experimental timelines, aliquot the solution into individual vials and freeze at -20°C to avoid repeated freeze-thaw cycles.

Regulatory & Safety Disclaimer