Quick Overview

High-purity Semaglutide (GLP-1 receptor agonist) synthesized specifically for in vitro laboratory research and development. Formulated as a sterile, lyophilized powder to ensure maximum stability and precision in cellular and experimental applications.

Product Description

Semaglutide is a potent, synthetic 31-amino-acid polypeptide that acts as a glucagon-like peptide-1 (GLP-1) receptor agonist. Modified structurally to resist rapid degradation by the dipeptidyl peptidase-4 (DPP-4) enzyme, it exhibits a significantly prolonged half-life in vitro. This makes it a highly valuable compound for scientific professionals studying cellular metabolic pathways, receptor binding kinetics, and cellular glucose homeostasis models.

Common Research Applications:

• Receptor Kinetics: Investigating GLP-1 receptor binding affinity and downstream cellular activation pathways.
• Enzyme Resistance: Studying the mechanisms of peptide protection against rapid DPP-4 degradation.
• Metabolic Studies: Observing the cellular down-regulation of glucagon secretion and assessing beta-cell functional responses.
• Assay Development: Analyzing prolonged half-life characteristics and lipopeptide behavior in various experimental assays.

Technical Specifications

Storage and Reconstitution

To maintain peptide integrity and stability, please adhere to standard laboratory handling guidelines:

• Lyophilized Form (Dry Powder): Store desiccated at -20°C (or below) upon receipt. While stable at room temperature for brief transit periods, long-term freezing is required to prevent degradation.
• Reconstitution: Reconstitute using bacteriostatic water or sterile water for injection. Introduce the diluent carefully and gently swirl the vial until dissolved. Do not shake vigorously, as this can fracture the peptide bonds.
• Liquid Storage (Reconstituted): Once reconstituted, the solution should be stored at 2°C to 8°C (refrigerated) and utilized within 30 days. For extended experimental timelines, aliquot the solution into individual vials and freeze at -20°C to avoid repeated freeze-thaw cycles.

Regulatory & Safety Disclaimer